Cigarettes also promote acid manufacturing in the abdomen, so there's extra to pass by means of the sphincter in the first place. The Lysine 65 Residue in HIV-1 Reverse Transcriptase Perform and in Nucleoside Analog Drug Resistance. Garforth SJ, Lwatula C, Prasad VR. The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance. Garforth, S.J.