Low carb, the 5:2 food regimen, detox, cabbage soup.. These carbonyl and hydroxyl oxygens have been proposed to facilitate the transfer of the methyl group throughout catalysis sixteen , 21 , 24 As well as, tyrosine residues within the lysine-binding clefts of SET7/9 (Tyr245 and lawyer Tyr305) and DIM-5 (Tyr178) hydrogen-bond to the lysine ε-amino group, aligning it for a methyltransfer with AdoMet (Determine 4b,c ).

The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and which are structurally not associated to SET-area proteins 4 - 6 Recent work means that SET-domain-containing proteins methylate a number of proteins in addition to histones (see later)