The enzymes concerned in lysine methylation were first discovered to focus on histone and thus were initially named histone methyltransferases and histone demethylases, following the naming model for histone acetyltransferase and legal professional histone deacetylase.

Methylation of proteins from budding yeasts (resembling Ipl Aurora kinase and ribosomal proteins) and vegetation (Rubisco subunits) has additionally been reported eleven , 183 - 185 It's conceivable that many proteins may be modified by lysine methylation, along with different forms of PTMs.

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